Thermodynamic analysis for synthesis of aspirin catalyzed by aluminum tripolyphosphate
- VernacularTitle:三聚磷酸铝催化合成阿司匹林的热力学分析
- Author:
Wei XIE
;
Jing WANG
;
Zengwei HUANG
;
Dongping WEI
;
Aiqun YUAN
;
Shaomei MA
- Publication Type:Journal Article
- Keywords:
thermodynamic analysis;
aluminum tripolyphosphate;
aspirin;
salicylic;
acetic anhydride
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):169-171,175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility using aluminum tripolyphosphate as the synthesis of aspirin model instead of sulfuric acid catalyst. Methods The thermodynamic functions of the reaction system of salicylic acid and acetic anhydride were calculated according to the Benson group contribution method and Joback group contribution method.The enthalpy change,entropy and Gibbs free energy along with the change of temperature as well as the influence of the molar rate of reactants on the equilibrium conversation rate were also studied.Results In the temperature range of 298.15 K to 358.15 K,the reaction enthalpy was less than zero,and was exothermic reaction,and increase of temperature was not conducive to the reaction.The improvement of mole ratio of salicylic acid and acetic anhydride was helpful to improve the equilibrium conversation rate.The theoretical conversion rate could reach 99.58% when the mole ratio of salicylic acid and acetic anhydride was 3.Conclusion From the viewpoint of thermodynamics, the reaction is practical and feasible.
