Expression and clinical significance of VEGF and Id-1 in ccervical cancer tissues
10.3760/cma.j.issn.1008-6706.2015.05.019
- VernacularTitle:血管内皮生长因子和细胞分化抑制因子联合检测在宫颈癌诊疗中的应用价值
- Author:
Guiying CAO
- Publication Type:Journal Article
- Keywords:
Colorectal adenocarcinoma;
Vascular endothelial growth factors;
Cell differentiation inhibitory factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(5):696-698,699
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression VEGF and Id -1 and its possible relationship with the c1inical pathological features of cervical cancer .Methods The expression of VEGF and Id -1 were examined in cer-vical cancer and normal tissues by immunohistochemical SP technique .Results The positive expression rate of VEGF in cervical cancer was 80.00%(48/60),which was significantly higher than that in normal tissues 6.67%(2/30)(P<0.01);The positive expression rate of Id -1 protein in cervical cancer was 73.34%(44/60),which was significantly higher than that in normal tissues 10.00%(3/30)(P<0.01);The expressions of VEGF and Id -1 were positively correlated with the degree of differentiation ,vascular invasion,and FIGO stage(P<0.05),and while was not significantly associated with age ,tumor size,lymph node metastasis ,and pathologic types .Expression of VEGF was positively related with expression of Id -1 in cervical cancer tissues(r=0.642,P=0.000).Multiple regression anal-ysis showed that:VEGF,Id -1,differentiation,vascular invasion,and FIGO were independent prognosis factors for cervical cancer .Conclusion The expressions of VEGF and Id -1 are correlated with the development of cervical cancer.Detection of the expression of VEGF and Id -1 in cervical cancer can predict the metastasis and prognosis , which can provide the basis for clinical targeted therapy .
