Correlation Analysis of the expression of HIF-1α and MRP in hepatocellular carcinoma
10.3969/j.issn.1673-4130.2015.14.034
- VernacularTitle:HIF-1α和 MRP的表达在肝癌组织中的相关性分析
- Author:
Dashuai LI
;
Ying CHEN
;
Xiaojing MA
- Publication Type:Journal Article
- Keywords:
hypoxia inducible factor;
multidrug resistance protein;
hepatocellular carcinoma;
correlation analysis
- From:
International Journal of Laboratory Medicine
2015;(14):2029-2030,2033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between liver tissue hypoxia inducible factor‐1α(HIF‐1α) protein expression and multidrug resistance protein (MRP) expression between .Methods Our hospital from March 2012 to March 2013 the Depart‐ment of Pathology of the liver paraffin‐embedded specimens of a total of 83 cases of specimen processing ,production of tissue sec‐tions ,HIF‐1αexpression was observed ,the positive expression of MRP .Results 83 cases of specimens in HIF‐1α 50 cases were positive ,the positive rate was 60 .2% ;of which the well‐differentiated tumor samples of HIF‐1α positive rate was 74 .1% ,signifi‐cantly higher than the 28 .0% poorly differentiated (P<0 .05);and the absence of lymph node metastasis positive rate of HIF‐1αwas no significant difference (P>0 .05) .In 83 cases of samples ,58 samples were MRP positive ,the positive rate was 70 .0% ;MRP positive rate among the high degree of 77 .6% ,significantly higher than the 52 .0% poorly differentiated (P<0 .05);and lymph node tumors MRP positive rate of metastasis were 76 .30 ,64 .4% respectively ,the difference was not statistically significant (P>0 .05) .MRP expression in the same samples were positive ,the HIF‐1α expression was also significantly increased .Conclusion HCC HIF‐1αprotein expression and MRP expression has some relevance .
