Relationship between cystatin C and severity of the disease and changes of renal function in patients with acute cerebral infarction
10.3969/j.issn.1673-4130.2015.14.055
- VernacularTitle:胱抑素C与急性脑梗死患者病情严重程度及肾功能变化的关系
- Author:
Qun SHI
- Publication Type:Journal Article
- Keywords:
cystatin C;
acute cerebral infarction;
renal function
- From:
International Journal of Laboratory Medicine
2015;(14):2077-2078,2080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between cystatin C (CysC) and severity of the disease and changes of renal function in patients with acute cerebral infarction .Methods A total of 84 patients with acute cerebral infarction (study group) and 84 healthy individuals (control group) were enrolled and serum CysC levels were detected ,and its relationship with the degree of neurological impairment was analysed .500 mL/d (group A) and 375 mL/d (B group) 20% mannitol treatment were used ,and changes of serum CysC levels and renal function before treatment and 5 days and 14 days after treatment were analyzed .Results Serum CysC levels in patients with large ,medium and small infarcts were significantly higher than that in the control group (P<0 .05) .Serum CysC levels in patients with heavy ,medium and mild nerve function defect were significantly higher than that in the control group (P<0 .05) .After treatment ,serum levels of CysC ,creatinine (Cr) and blood urea nitrogen (BUN) in group A and B were increased ,in which serum CysC levels were significantly higher than that before treatment (P<0 .05) .5 and 14 days after treatment ,serum levels of CysC ,Cr and BUN in group A and B were without significant differences(P>0 .05) .Conclusion CysC might be closely related with the severity of acute cerebral infarction ,which could be more useful for monitoring renal function of patients with cerebral infarction than Cr and BUN .
