Diagnostic value of growth hormone stimulating test in dwarfism of children and related influencing factors
10.3969/j.issn.1673-4130.2015.08.010
- VernacularTitle:生长激素激发试验在矮小症儿童诊断中的价值及可能影响因素
- Author:
Xiangquan LIN
;
Xin YUAN
- Publication Type:Journal Article
- Keywords:
dwarfism;
stimulating test;
insulin growth factor-1;
25-hydroxyl vitamin D
- From:
International Journal of Laboratory Medicine
2015;(8):1036-1037,1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of growth hormone(GH) stimulating test in dwarfism of children and related influencing factors .Methods Arginine and L‐dopa were applied to perform GH stimulating test in 642 children with dwarf‐ism .GH levels were detected at 30 ,60 ,90 ,120 ,150 ,180 min after stimulation .All children were divided into GH deficiency (GHD) group ,with peak value of GH less than 10 ng/mL ,and non‐GHD group ,with peak value of GH at least 10 ng/mL .Physical and la‐boratory data of the two groups were compared .Results The proportion of children with GHD and without GHD were 68 .69%and 31 .31% ,respectively ,and with statistical difference(χ2 =6 .19 ,P<0 .05) .The GH peak value ,with a delay ,mainly appeared at 30 and 150 min after stimulation ,accounting for 22 .42% and 34 .27% .Levels of age ,body height standard deviation ,body mass in‐dex ,alanine aminotransferase ,aspartate aminotransferase ,insulin growth factor‐1 and 25‐hydroxyl vitamin D were statistically dif‐ferent between the two groups(P<0 .05) .Conclusion Arginine and L‐dopa combined stimulating test could be used for the diagno‐sis of GHD in children with dwarfism .GH level might be correlated with various physical and laboratory parameters ,which should be considered for the diagnosis of GHD .
