Change of CD45RA+and CD45RO+T cell in peripheral blood in peripheral T-cell lymphoma patients before and after CHOP chemotherapy
10.3969/j.issn.1000-484X.2015.04.020
- VernacularTitle:CHOP方案治疗前后外周 T 细胞淋巴瘤患者外周血 CD45 RA＋T 和CD45 RO＋T的变化特点
- Author:
Bo WANG
;
Yangqiu LI
- Publication Type:Journal Article
- Keywords:
Peripheral T cell lymphoma;
CHOP;
naive T cells;
Memory T cells
- From:
Chinese Journal of Immunology
2015;(4):531-533,536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the change of initial and memory T cells in peripheral blood and their clinical significance in peripheral T cell lymphoma patients( PTCL) before and after CHOP chemotherapy.Methods:The proportion of CD4+CD45RA+T cells and CD4+CD45RO+T cells,CD8+CD45RA+T cells and CD8+CD45RO+T cells in peripheral blood from 20 PTCL patients before and after chemotherapy was detected by flow cytometry, the relationship between curative effect and T cell subset was further analyzed.Results:Before treatment,the proportion of CD4+and CD4+CD45RO+T cells in PTCL patients was significantly lower than that from the control group,while the proportion of CD4+CD45RA+,CD8+,CD8+CD45RO+and CD8+CD45RA+T cells was significantly higher( P<0.05 );after treatment, proportion of CD4+, CD4+CD45RO+T was significantly increased, CD4+CD45RA+, CD8+, CD8+CD45RO+,CD8+CD45RA+T was slightly decreased( P<0.05).Before and after treatment,higher proportion of CD4+CD45RA+T cells was found in response group compared with no response group.Conclusion: CHOP chemotherapy might influence the thymic output function in PTCL patients,patients with higher thymic output function may have better response to chemotherapy.
