Optimization of Prescription for Double-layered Erhuang Sustained-release Suppository by ;Multi-index Orthogonal Experiment
10.3969/j.issn.1005-5304.2015.05.023
- VernacularTitle:多指标正交试验优化儿黄缓释双层栓处方
- Author:
Zhu ZHENG
;
Jizong JIANG
;
Bo FU
;
Fengjuan HAN
;
Yanhong WANG
- Publication Type:Journal Article
- Keywords:
Erhuang Powder;
double-layer sustained-release suppository;
prescription;
preparation technology
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(5):85-87,88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize prescription for double-layered Erhuang sustained-release suppository. Methods Amounts of PEG400, PEG4000, HPMC were selected as influence factors for L9(34) orthogonal experiment. A comprehensive assessment was conducted by setting the cumulative release degree at three different time points as index, and the inner and outer layers of double-layered Erhuang sustained-release suppository were optimized. Results The best prescription was the inner HPMC∶PEG4000∶PEG400=1.5∶10∶4;outer HPMC∶PEG4000∶PEG400=0.5∶10∶4. Conclusion Prescription for double-layered Erhuang sustained-release suppository has good forming property and a good sustained-release effect according to the optimized prescription, which has certain reference value for researches and development of TCM suppository.
