Correlation between overexpression of PC4 in lung adenocarcinoma with lymph node metastasis
10.3969/j.issn.1671-8348.2015.11.003
- VernacularTitle:肺腺癌人转录辅助因子4过表达与淋巴转移的相关性
- Author:
Tianyu SUN
;
Qunyou TAN
;
Chunmeng SHI
;
Ruwen WANG
;
Bo DENG
;
Jinghai ZHOU
;
Shaolin TAO
;
Poming KANG
- Publication Type:Journal Article
- Keywords:
lung;
adenocarcinoma;
human transcriptional positive cofactor 4;
polymerase chain reaction;
immunohistochemis-try;
lymphatic metastasis
- From:
Chongqing Medicine
2015;(11):1449-1451,1456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the promotion effect of human transcriptional positive cofactor 4 (PC4) overexpression on lymphatic metastasis in lung adenocarcinoma .Methods 96 samples of lung adenocarcinoma tissue were collected .The immuno‐histochemistry(IHC) and real‐time quantitative polymerase chain reaction (qRT‐PCR) were adopted for detecting the expression levels of PC4 protein and mRNA .The correlation of PC4 expression with lymphatic metastasis and TNM stage was analyzed .Re‐sults The expression of PC4 protein was positively correlated mRNA in lung adenocarcinoma (r=0 .63 ,P<0 .01);the expression of PC4 protein was positively correlated with lymph node metastasis (χ2 =8 .29 ,P<0 .01) and TNM stage (χ2 =4 .71 ,P<0 .05);the expression of PC4 mRNA was also positively correlated with lymph node metastasis (χ2 = 8 .40 ,P< 0 .01) and TNM stage (χ2 =5 .10 ,P<0 .05) .Conclusion PC4 overexpression is found to be closely associated with the lymph node metastasis and TNM stage .PC4 may facilitate the lymph node metastasis of lung adenocarcinoma .
