Autoimmune research on nerve root injury induced by non-compressive nucleus pulposus protrusion
10.3969/j.issn.1000-484X.2015.04.024
- VernacularTitle:非压迫性椎间盘髓核突出致神经根损伤中自身免疫反应的研究
- Author:
Weijie YUAN
;
Ziwei YUAN
;
Ruiying WANG
;
Junzu HU
- Publication Type:Journal Article
- Keywords:
Non-compressive;
Nucleus pulposus;
Autoimmunity;
Nerve root
- From:
Chinese Journal of Immunology
2015;(4):545-547,550
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the autoimmune response on the mechanism and clinical significance of nerve root injury induced by the non-compressive nucleus pulposus protrusion.Methods:Forty-eight female SD rats were randomly divided.Twenty-four female SD rats were recruited as model group,and the others as control.After ten days,twenty days and forty days,the pain threshold of left hind leg and the levels of TNF-α, CD4+, CD8+T cells were measured, the nerve root changes in morphology were observed by HE.Results:Compared with the control group,model group in ten days,twenty days,which left hind leg pain threshold,the proportion of CD4,CD8+T cell and the expression of TNF-αare significantly different.After forty days,these two groups have no statistical differ-ence.After ten days,lumbar nerve root cross-sectional myelin of model group was partial disintegrated.The worst damage happened in twenty days,and almost recovered to normal in forty days.Conclusion:T cell-mediated autoimmunity and TNF-αplay an important role to the nerve root injury in the early time of the non-compressive nucleus pulposus protrusion.
