The therapeutic effects of Fuyanshu Capsule on chronic endometritis in rats
10.7652/jdyxb201503024
- VernacularTitle:妇炎舒胶囊对慢性子宫内膜炎大鼠的治疗作用及其机制
- Author:
Pu HUANG
;
Jun ZHOU
;
Gang CUI
;
Baode YANG
;
Wenbao ZHAO
;
Chuanhao LIU
;
Hao HU
- Publication Type:Journal Article
- Keywords:
Fuyanshu Capsule;
endometritis;
phenol mucilage;
inflammatory cytokine
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(3):404-407,413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Fuyanshu Capsule on phenol mucilage-induced endometritis rats and the possible anti-inflammation mechanism of the therapeutic effects.Methods Chronic endometritis in rats was induced by injection of phenol mucilage suspension into the uterus.Sixty female SD rats were randomly divided into 6 groups,namely,sham-operation group (distilled water,10mL/kg),model group,Jinji capsule group (0.65 g/kg),and Fuyanshu Capsule groups (1.8 g/kg,0.9 g/kg and 0.45 g/kg).After the rats were treated 28 days with corresponding medicine by intragastric administration,the pathology of the endometrium and changes of tumor necrosis factor α(TNF-α)and interleukin-2 (IL-2)levels were detected to evaluate the effects of Fuyanshu Capsule. Results Fuyanshu Capsule (1.8 g/kg and 0.9 g/kg)ameliorated the body weight reduction caused by endometritis in rats.Fuyanshu Capsule (1.8 g/kg,0.9 g/kg and 0.45 g/kg)reduced the ratio of the swelling uterus and ovaries to body weight of the rats.It ameliorated obviously the hyperplasia,necrosis and degeneration of endometrial epithelia and infiltration of inflammatory cells.The capsule (1.8 g/kg)decreased the serum IL-2 level in the rats with phenol mucilage-induced endometritis. Conclusion The anti-inflammatory effect of Fuyanshu Capsule on chronic endometritis induced by phenol mucilage in rats may be related to the decrease of IL-2 level.
