Expressions of IL-6 and IL-8 in lung injuries induced by blunt chest trauma
10.3969/j.issn.1671-8348.2015.10.007
- VernacularTitle:炎症介质 IL-6及 IL-8在撞击伤肺组织中的表达研究
- Author:
Qiuping WU
;
Li JIANG
;
Zaiyong ZHANG
;
Jiaxin MIN
- Publication Type:Journal Article
- Keywords:
thoracic injuries;
impact injury;
interleukin-6;
interleukin-8
- From:
Chongqing Medicine
2015;(10):1317-1318,1321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of IL-6 and IL-8 in the lung injuries induced by blunt chest trauma under the closure and open state of glottis.Methods The expressions of IL-6 and IL-8 mRNA were detected by RT-PCR in injuried lung tis-sues under the closed and open glottis states snd the control lung tissues at designed different time points.Results The expressions of IL-6 and IL-8 mRNA at 4,8,12h in the closed glottis group were obviously higher than those in the open glttis group (P <0.05) and the expressions at designed various time points in the injured lung tissue were higher than those in the control lung tissues (P <0.05).The change rule of IL-6 and IL-8 mRNA expression in the control group,closed glottis group and open glottis group was similar,the expression was up-regulated.Conclusion IL-6 and IL-8 might play an important role in the occurrence and develop-ment of functional lesion in the injured lung by blunt chest trauma.
