Pharmacodynamics Study of Different Lactone Ratios of Hydroxycamptothecin on Mice Models of H22 Hepatoma
10.3870/yydb.2015.04.013
- VernacularTitle:不同内酯型比例羟喜树碱对H22肝癌模型小鼠药效学
- Author:
Rong WANG
;
Wei HU
;
Song WU
;
Yun FANG
- Publication Type:Journal Article
- Keywords:
Hydroxycamptothecin;
Mouse model of H22 hapatoma;
Lactone ratio;
Pharmacodynamics
- From:
Herald of Medicine
2015;(4):471-474,475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-tumor effects of hydroxycamptothecin ( HCPT ) with different lactone ratios on the mice models of H22 hepatoma. Methods Mice models of H22 hepatoma were established. Tumor inhibiting rates of HCPT with different lactone ratios ( 0%, 25%, 50%, 75%, 100%) and the growth status of model mice before and after chemotherapy were observed. Serum biochemical indices were determined to investigate the effects of HCPT with different lactone ratios on hepatic and renal function of the mice. Results Positive control drug and HCPT with different lactone ratios all inhibited the tumor in mice with H22 hepatoma, the inhibition rate was 65. 30%, 12. 57%, 49. 23%, 75. 47%, 90. 06% and 93. 22%, respectively. Compared with the model control group, the living conditions of the mice in HCPT groups were improved. With increasing of lactone ratios, the hepatic injury was alleviated markedly, but the renal injury was aggravated. Conclusion There is a positive correlation between lactone ratios and its anti-tumor effect, and HCPT with 75% lactone can achieve preferable anti-tumor effect with less toxicity as compared with that with 100% lactone ratio.
