Relationship between schizophrenic′s executive function and ERP-P300 in a Go/Nogo paradigm

VernacularTitle:精神分裂症患者执行功能与Go／Nogo范式事件相关电位P300的关系
Author: Haorui DU ; Junlin MU ; Liuyi LI ; Hua ZHENG ; Deeng SANG ; Hongxing ZHANG
Publication Type:Journal Article
Keywords: Schizophrenia; executive function; Go/NogoERP-P300; amplitude; latency
From: The Journal of Practical Medicine 2015;(8):1238-1240,1241
CountryChina
Language:Chinese
Abstract: Objective To explore schizophrenic′s executive function and characteristics of event-related potential-P300 (ERP-P300) in a Go/Nogo paradigm in order to provide electrophysiological basis for schizophrenic′s executive function. Methods The Wisconsin card Sorting Tests (WCST) were conducted and ERP-P300s in a Go/Nogo paradigm (Go/NogoERP-P300) were determined in 58 schizophrenics and 30 healthy persons. Results The WCST score was poorer in research group than that in control group. ERP amplitudes lowered and latencies prolonged in Go-P3 and Nogo N2 and P3, and all differences had statistical significances (P < 0.05). But there were no differences in N1 of both tasks and Go-N2; Go-P3, Nogo-N2 and -P3 amplitude and latency were related to the WCST well (P < 0.05). Conclusion Schizophrenics have such lowered executive functions as attention and cognition conversion and reactive inhibition and could normally process task prophase merely , and Go/NogoERP-P300 may be one of electrophysiological methods reflecting schizophrenic′s executive function.