Role of AGXT2 in ADMA metabolism and the development of cardiovascular and cerebrovascular diseases
10.3969/j.issn.1001-1978.2015.05.003
- VernacularTitle:AGXT2与ADMA代谢及心脑血管疾病的研究进展
- Author:
Xiaolei HU
;
Jipeng ZHOU
;
Xiaoping CHEN
- Publication Type:Journal Article
- Keywords:
ADMA;
SDMA;
AGXT2;
dimethylarginine dimeth-ylaminohydrolase;
SNP;
cardiovascular and cerebrovascular dis-eases
- From:
Chinese Pharmacological Bulletin
2015;(5):601-604,605
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular and cerebrovascular diseases have be-come a great health threat.Increasing evidence has shown that both asymmetric dimethylarginine (ADMA)and symmetric dim-ethylarginine (SDMA)play important and independent roles in the development of cardiovascular and cerebrovascular diseases as well as in the prediction of cardiovascular and cerebrovascular events.Alanine-glyoxylate aminotransferase 2 (AGXT2 )is re-cently observed to be involved in ADMA metabolism.Deficiency in the expression and activity of AGXT2 may thus play a role in the development of cardiovascular and cerebrovascular diseases by affecting ADMA levels in vivo.Several single-nucleotide poly-morphisms at AGXT2 locus are observed to be associated with plasma SDMA level.This review summarizes recent advances in AGXT2 and its role in ADMA metabolism and the clinical rele-vance.
