Advances in research on signal transduction mechanisms and their inhibitors for the proliferation of pulmonary artery smooth muscle cells
10.3969/j.issn.1001-1978.2015.05.004
- VernacularTitle:参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展
- Author:
Mingxing LI
;
Yong WANG
;
Deqi JIANG
;
Yan WANG
;
Shanshan YU
- Publication Type:Journal Article
- Keywords:
pulmonary artery hypertension;
PASMCs;
prolifera-tion;
signal transduction mechanisms;
signal transduction inhibi-tors;
progress
- From:
Chinese Pharmacological Bulletin
2015;(5):605-609,610
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary artery hypertension (PAH ) is a chronic progressive disease characterized by a persistent elevation of pul-monary vascular pressure,and the disease would limit the right ventricular function severely,fail the organ and even lead to death in the end.The histopathological change of PAH is fea-tured by the restructuring of pulmonary vessels,and the abnor-mal reproduction of pulmonary artery smooth muscle cells (PASMCs)in peripheral vessels is the major pathological basis of pulmonary vascular restructuring.This paper mainly reviews the research advances on signal transduction mechanisms and their inhibitors in promoting the proliferation of pulmonary artery smooth muscle cells.
