Clinicopathological significance of pEZRThr567 expression in lung squamous carcinoma
10.3969/j.issn.1000-4718.2015.05.032
- VernacularTitle:pEZRThr567在肺鳞癌中的表达及临床病理学意义
- Author:
Yuan ZHANG
;
Chenglong JIN
;
Shentong WANG
;
Yang YANG
;
Zhenhua LIN
;
Tiefeng JIN
- Publication Type:Journal Article
- Keywords:
Lung squamous carcinoma;
Ezrin;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
2015;(5):947-949,955
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the clinicopathological significance of the protein expression of phosphorylated ezrin at threonine 567 ( pEZRThr567 ) in lung squamous cell carcinoma, adjacent tissues and normal tissues.METHODS:pEZRThr567 protein was detected in lung squamous carcinoma, adjacent and normal tissues by the method of immunohisto-chemistry.The correlation of pEZRThr567 expression with clinicopathological parameters of lung squamous carcinomas was al-so analyzed.The localization of pEZRThr567 was detected by immunofluorescence staining in lung squamous cell line EBC-1. RESULTS:The protein expression of pEZRThr567 in lung squamous carcinoma was significantly higher than that in the adja-cent and normal lung tissues (P<0.01).pEZRThr567 mainly localized on the cell membrane, and its over-expression signi-ficantly correlated with the differentiation, clinical stage and lymph node metastasis in lung squamous carcinoma.CON-CLUSION:pEZRThr567 may be an effective biomarker for prediction of malignant potential and poor prognosis of lung cancer.
