Effect of scale method on vancomycin through concentration and nephrotoxicity in ICU patients
- VernacularTitle:万古霉素量表法用药对重症监护室患者药物谷浓度及肾毒性的影响
- Author:
Kun GAO
;
Bin ZHANG
;
Mingdi CHEN
;
Yuhong ZHANG
;
Huibang REN
- Publication Type:Journal Article
- Keywords:
vancomycin;
scale method;
nephrotoxicity
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):101-103,106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the vancomycin trough concentration and nephrotoxicity in ICU patients with scale method.Methods The patients in ICU were evaluated from September 2011 to December 2013 in the hospital by prospective randomized controlled study.Experience using drug was applied in control group (n=116).Scale method was applied in test group (n=117), vancomycin concentration and renal toxicity were compared between two groups.Results The percentage of patients with an initial vancomycin trough concentration 15.0μg/mL or higher increased in the test group as compared with control group (73%vs 38%, P=0.004).The test group also demonstrated that an increase in the percentage of patients with initial trough concentration from 15.0 to 20.0μg/mL (41% vs.19%, P=0.008), and no statistical difference in the percentage of patients with an initial vancomycin trough concentration above 20μg/mL (31% vs.17%, P=0.340).There was no difference in nephrotoxicity in test group compared with control group (17% vs.16%, P=0.953).Conclusion Use of scale method increases the percentage of initial vancomycin trough concentrations 15.0μg/mL or higher in ICU patients and is not associated with an increased occurrence of nephrotoxicity.
