Research of forming technology for Chuansu Jiuxin dropping pills
- VernacularTitle:川苏救心滴丸成型工艺研究
- Author:
Jianfeng JU
;
Yongli WEI
- Publication Type:Journal Article
- Keywords:
Chuansu Jiuxin dropping pills;
forming technology;
orthogonal experiment;
PEG4000;
PEG6000
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):173-175,180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the forming technology of Chuansu Jiuxin dropping pills.Methods The pills were prepared by dropping method.The forming technology of the pills was optimized by single factor test and orthogonal experiment by using the amount of PEG4000 to PEG6000, ratio of drug-matrix ,dropping temperature and speed as factors and with pill weight RSD,the time limit of collapse and appearance quality of the pills as evaluation indexes.Results Using PEG 4000 and PEG 6000 as matrix with the ratio of 4:1 and dimethyl silicone oil(100 mPa· s)as refrigerant at 5~15℃,the optimized parameters for the forming technology were as follows:the ratio of herbal extract to matrix was 1:3,the dropping temperature was at 90 ℃ and the dropping speed was 35 drops per minute,dropping from 4 cm.Conclusion The optimized technology is sample and feasible,and can provide a reference for industrial production of Chuansu Jiuxin dropping pills.
