Application of human papillomavirus genotype combined with thinprep cytologic test in diagnosis of cervical lesion
10.3969/j.issn.1673-4130.2015.11.016
- VernacularTitle:人乳头状瘤病毒基因分型联合薄层液基细胞学检测在宫颈病变筛查中的应用
- Author:
Kaizhen WEN
;
Rongjun ZHANG
;
Shuling WU
;
Yirong ZHANG
;
Zhimin BAI
- Publication Type:Journal Article
- Keywords:
human papillomavirus;
genotype;
thinprep cytologic test;
cervical lesion
- From:
International Journal of Laboratory Medicine
2015;(11):1518-1519,1522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of human papillomavirus(HPV )genotype combined with thinprep cytologic test(TCT )in the diagnosis of cervical lesion .Methods A total of 473 patients were checked for 21 subtypes of HPV by diversion hybrid gene chip technology ,TCT and colposcope biopsy were also detected at the same time .The histology was selected as a gold standard to analyze the tested results .Results The over all positive rate of HPV in 473 patients was 35 .7% .The positive rate of high risk HPV(HR‐HPV) was 32 .1% ,the positive rate of TCT was 26 .6% ,the sensibility ,specificity ,false negative rate , positive predictive value and negative predictive value between HR‐HPV detection and TCT detection were no statistical signifi‐cance(χ2 = 3 .444 ,P= 0 .063) .The sensibility ,specificity ,false negative rate ,positive predictive value and negative predictive value of combining test were 95 .8% ,77 .7% ,4 .2% ,52 .3% and 98 .7% ,the sensibility and negative predictive value improved notably , and the omission diagnose rate decreased significantly(P< 0 .05) .Conclusion HPV genotype combined with TCT detection could significantly improve sensibility and negative predictive value and decrease omission diagnose rate in diagnosis of cervical lesion .
