Comparison of two methods detecting fibrinogen on Sysmex CA7000
10.3969/j.issn.1673-4130.2015.11.028
- VernacularTitle:Sysmex CA7000血凝仪2种方法测定纤维蛋白原结果的比较
- Author:
Tongqing CHEN
- Publication Type:Journal Article
- Keywords:
fibrinogen;
Clauss method;
prothrombin time derivative algorithm method
- From:
International Journal of Laboratory Medicine
2015;(11):1546-1547,1549
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the accuracy of using prothrombin time (PT ) derivative algorithm(PT‐Fib) method to detect fibrinogen(Fib)content in plasma samples with Sysmex CA7000 automatic coagulometer and its correlation with results of Clauss method .Methods Clauss method and PT‐Fib method were used to detect Fib concentration in plasma of patients′ blood samples by Sysmex CA7000 automated blood coagulation analyzer and supporting reagent .Data were randomly collected as the Fib content were in 1 .00 - 1 .99 ,2 .00 - 2 .99 ,3 .00 - 3 .99 ,4 .00 - 4 .99 g/L detected by PT‐Fib method ,each range with 21 patients .The difference and correlation of two methods were analyzed .Results There was significant statistical difference between PT‐Fib meth‐od and Clauss method(P< 0 .05) when the level of Fib detected by PT‐Fib method were 1 .00 - 1 .99 ,2 .00 - 2 .99 ,3 .00 - 3 .99 , 4 .00 - 4 .99 g/L (n= 21) .The result of the PT‐Fib method was obviously lower than those of the Clauss method on average 15 .2%( - 4 .9% - 38 .3% ) ,27 .2% ( - 0 .9% - 49 .4% ) ,24 .6% ( - 3 .7% - 35 .6% )and 32 .7% (15 .7% - 48 .2% )respectively ,and results of the two methods were positively correlated .Conclusion Fib value calculated by the PT‐Fib method in the fully automatic coagu‐lation Sysmex CA7000 analyzer is obviously lower than that of the Clauss method .It is suggested that the Fib detection should be changed to adopt Clauss method while detecting Fib content in plasma samples with Sysmex CA7000 automatic coagulometer .
