Study on the distribution of auto-antibodies against platelet in adults and children with primary immune thrombocytopenia in Nanning
10.3969/j.issn.1673-4130.2015.11.009
- VernacularTitle:南宁地区成人及儿童ITP患者体内血小板自身抗体特异性分布的研究
- Author:
Yan ZHOU
;
Zhoulin ZHONG
;
Jinlian LIU
- Publication Type:Journal Article
- Keywords:
thrombocytopenia;
platelet membrane glycoprotein;
autoantibody;
distribution
- From:
International Journal of Laboratory Medicine
2015;(11):1500-1501,1504
- CountryChina
- Language:Chinese
-
Abstract:
Objective Study on the distribution of auto‐antibodies against platelet in adults and children with primary immune thrombocytopenia(ITP) .Methods Platelet auto‐antibodies were detected in 83 ITP patients and 58 non‐ITP patients by enzyme linked immunosorbent assay (PAKAUTO kit) .Anti‐GP Ⅱ b/Ⅲ a ,GP Ⅰ b/Ⅸ and GP Ⅰ a/Ⅱ a auto‐antibodies were analyzed for 46 a‐dults and 37 children with ITP .Results The positive rate of autoantibody was 66 .27% in ITP patients ,which was much higher than that of non‐ITP patients ,the difference was significant(P < 0 .05) .As for ITP patients ,female ITP patients in adult group were 28 ,while in children group were 24 ,the difference was not significant(P > 0 .05) ,but the morbidity of ITP in females was higher than that of males in both of the two groups ,the difference was significant(P< 0 .05) .There was no significant difference on the distribution of platelet auto‐antibodies in adult and children group(P> 0 .05) ,the main of them was resistance against GP Ⅱ b/Ⅲ a and GP Ⅰ b/Ⅸ antibodies .Conclusion The detection of platelet auto‐antibodies could distinguish ITP and non‐ITP patients ,and GP Ⅰ a/Ⅱ a has an important reference value about therapy .
