The risk factors for mortality in non-human immunodeficiency virus infected children with pneumocys-tis carinii pneumonia
10.3760/cma.j.issn.1673-4912.2015.05.001
- VernacularTitle:非人类免疫缺陷病毒感染儿童肺孢子菌肺炎死亡风险因素分析
- Author:
Kun LIAO
;
Suyun QIAN
;
Jiansheng ZENG
;
Xinlei JIA
;
Zheng LI
;
Jun LIU
;
Hengmiao GAO
- Publication Type:Journal Article
- Keywords:
Non-human immunodeficiency virus infection;
Pneumocystis carinii pneumonia;
Epide-miology;
Risk factors;
Mortality;
Children
- From:
Chinese Pediatric Emergency Medicine
2015;22(5):289-293,294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the epidemiologic characteristics and risk factors for mortality in non-(human immunodeficiency virus,HIV) infected children with pneumocystis carinii pneumonia(PCP). Methods The data of non-HIV infected children with PCP diagnosed in Beijing Children′s Hospital from January 1,2006 to December 31,2012 were collected. They were divided into survival and non-survival group according to the prognosis. The epidemiologic characteristics and risk factors for mortality were analyzed. Results Sixteen patients were enrolled in this study. Ten of them survived and 6 of them were non-survived. The basic diseases included malignant tumor in 5 patients and non-malignancy diseases in 11 of them. Com-pared with the survival group,the non-survival group had a higher average age [(12. 00 ± 2. 00) years vs. (6. 65 ± 4. 32)years,P=0. 01],higher ratio to need mechanical ventilation (6/6 vs. 4/10,P=0. 04),lower PaO2/FiO2[(73. 88 ±26. 95) mmHg vs. (167. 50 ± 97. 17) mmHg,1 mmHg=0. 133 kPa,P=0. 01] and lower pediatric critical illness score(75. 67 ± 5. 72 vs. 86. 40 ± 8. 88,P=0. 02). There were no differences on sex ratio,kinds of basic diseases,whether with co-infections,the time of immunosuppressant administration, the time from onset to diagnosis,the time from onset to beginning trimethoprim-sulfamethoxazole therapy, PaCO2 ,white blood cell counts,lymphocyte counts,CD4+ cell counts,C-reactive protein,and hemoglobin con-centrations between the survival and non-survival group. Conclusion A higher age, need for mechanical ventilation,lower PaO2/FiO2 and lower pediatric critical illness score were risk factors for mortality in non-HIV infected children with PCP.
