The role of soluble urokinase plasminogen activator receptor detection in sepsis judgment and prognos-tication
10.3760/cma.j.issn.1673-4912.2015.050.14
- VernacularTitle:可溶性尿激酶型纤溶酶原激活物受体检测在脓毒症诊断及预后评估中的作用
- Author:
Xiaohui WU
;
Cuiping ZHU
- Publication Type:Journal Article
- Keywords:
Soluble urokinase plasmni ogena tc ivator ecetp or;
Sepsis;
Biomarker;
Children
- From:
Chinese Pediatric Emergency Medicine
2015;22(5):341-343,347
- CountryChina
- Language:Chinese
-
Abstract:
Sepis s is the leading cause of death in critically ill children,but it lack biomarkers with a higher sesn itivity and specificity for sepsis diagnosis,severity assessment,and prognostication.Soluble uroki-nase plasminogen activator receptor( suPAR) ,as a nvo el receptor ts imual ted by inflammation,is involved in the plasminogen activating pathways,inflammation and migration,adhesino ,chemotaxis,signal transduction of v ra ious immuen cell.suPAR serum levels have been shown to significantly incer ase in various infectious dis-easse .This revei w provided a ed scriptive overview of the role of suPARd etection in sepsis judgmne t and prognostication,hoping to find a perfetc biomarker for timely evaluait ng of chidlr en with spe sis and screening for childrena dmitted to the intensive care uin t in order to improve outcome and reduce mortality.
