Study on relationship between IL-6, IL-8 and Helicobacter pylori in patients with gastric cancer
- VernacularTitle:白介素6、白介素8与胃癌患者幽门螺杆菌关系研究
- Author:
Jing WANG
;
Chunchun YANG
;
Fengchun LI
- Publication Type:Journal Article
- Keywords:
gastric cancer;
IL-6;
IL-8;
precancerous lesion;
Helicobacter pylori
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(5):143-145,149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relationship between IL-6, IL-8 and Helicobacter pylori in patients with gastric cancer.Methods 264 cases patients with gastric cancer and gastritis were selected, and divided into control group, precancerous lesion group and gastric cancer group according to the tissue biopsy, then each group were divided into positive group and negative group according to 12 C test.IL-6 and IL-8 in serum and gastric juice were detected by ELISA, while in gastric mucosa by double antibody sandwich method.Results Compared with control group, IL-6 and IL-8 in serum, gastric juiceand gastric mucosa were higher ( P<0.05 ) .Compared with precancerous lesion group, IL-6 and IL-8 in serum, gastric juice and gastric mucosa were higher(P<0.05).Compared with Hp negative group, IL-6 and IL-8 in serum, gastric juice and gastric mucosa were higher(P<0.05). Compared with gastric cancer group, Hp eradication rate of precancerous lesion group and control group was higher, respectively ( P<0.05 ) . Conclusion IL-6 and IL-8 in gastric cancer patients’ serum, gastric juice and gastric mucosa increased, which is higher in Hp positive group.The levels of IL-6, IL-8 maybe the key mechanism of the formation of gastric cancer, which has important sense of assessment and diagnosis of gastric cancer.
