Value of serum microRNA-199a/b-3p on early diagnosis of hepatocellular carci-noma
10.3969/j.issn.1000-484X.2015.05.023
- VernacularTitle:早期肝细胞癌患者循环microRNA-199 a／b-3 p的检测及临床意义
- Author:
Xuguang MI
;
Lei LIU
;
Shouqing LI
;
Yanqiu FANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
microRNA-199a/b-3p;
Serum;
AFP
- From:
Chinese Journal of Immunology
2015;(5):683-685,689
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression levels of serum microRNA-199a/b-3p ( miR-199-3p) in hepatocellular carcinoma (HCC) patients and to explore whether miR-199a/b-3p could be a novel biomarker of early HCC.Methods: Patients with normal liver,liver cirrhosis and early HCC in clinic were included in this study.Blood samples of the patients were collected for analy-sis.Real time quantitative PCR technique was used to measure the expression level of serum miRNA-199a/b-3p.The AFP expression was got from clinical data.Results: Comparing with normal liver and liver cirrhosis patients, miRNA-199a/b-3p presented lower expressions in early HCC patients (P<0.05);the accuracy and positive rate of serum miR-199a/b-3p detection in cirrhosis and HCC were better than AFP detection.Conclusion:Data indicated that miRNA-199a/b-3p had diagnostic value for indicating liver cirrhosis and early HCC.
