Autoantibodies and inflammatory cytokines in children with systemic-onset juvenile idiopathic arthritis
10.3969/j.issn.1673-4130.2015.10.010
- VernacularTitle:全身型幼年特发性关节炎患儿自身抗体和炎性细胞因子研究
- Author:
Xilu CHEN
- Publication Type:Journal Article
- Keywords:
system-onset juvenile idiopathic arthritis;
autoantibodies;
inflammatory cytokines
- From:
International Journal of Laboratory Medicine
2015;(10):1344-1345,1348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of autoantibodies and inflammatory cytokines in children with system‐onset ju‐venile idiopathic arthritis (So‐JIA) .Methods Serum concentrations of autoantibodies and inflammatory cytokines were measured in children with So‐JIA at active phase or remission phase by using indirect immunofluorescence method and enzyme‐linked immu‐nosorbent assay .Healthy children were enrolled as control group .Results The assay positivity of antikeratin antibody (AKA) and anti‐cyclic citrullinated peptide antibody (anti‐CCP) was 29 .4% and 47 .1% in active phase group ,and was 17 .2% and 27 .6% in remission group .The differences between the two groups were significant (P<0 .05) .The diagnostic sensitivity of AKA and anti‐CCP was 21 .1% and 41 .3% ,and the diagnostic specificity was 97 .2% and 91 .9% .The diagnostic sensitivity of anti‐CCP was higher than AKA .Serum levels of anti‐CCP ,interleukin‐6 (IL‐6) and interleukin‐17 (IL‐17) of active phase group were higher than remission phase group and control group (P<0 .05) ,and those of remission phase group were higher than control group ,but the differences were not significant (P>0 .05) .Conclusion AKA and anti‐CCP might be with high diagnostic specificity to So‐JIA ,but the sensitivity could be low ,and combined detection could increase the diagnostic positivity .Inflammatory cytokines ,such as IL‐6 and IL‐17 ,might be associated with the activity of So‐JIA ,which could be important biomarkers of So‐JIA .
