Application of MLPA for analysis of chromosomal unbalances
10.3969/j.issn.1673-4130.2015.10.007
- VernacularTitle:应用MLPA技术分析非平衡性染色体结构异常
- Author:
Rungui XIE
;
Jiwu LOU
;
Yanhui LIU
;
Yangyang LIN
- Publication Type:Journal Article
- Keywords:
multiplex ligation-dependent probe amplification;
chromosomal unbalance;
chromosome;
karyotype
- From:
International Journal of Laboratory Medicine
2015;(10):1336-1337,1340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To valuate the applicability of multiplex ligation‐dependent probe amplication (MLPA ) for detection of chromosomal unbalance .Methods Aneuploid and subtelomeric MLPA technology were used to analyze 6 samples with chromosom‐al unbalances ,confirmed by karyotype analysis .Results All samples were identified to have abnormal signal of corresponding probes .The extent of unbalances contained subtelomeric region .Conclusion MLPA technology could have important role in diag‐nosis of chromosomal unbalance ,which could complement conventional karyotype analysis .
