Inlfuence of High Density Lipoprotein Cholesterol Upon Carotid Artery Structure and Elasticity：Assessed with Ultrasound Radio Frequency-data Technique
10.3969/j.issn.1005-5185.2015.05.005
- VernacularTitle:超声射频信号技术评价高密度脂蛋白胆固醇对颈动脉结构和弹性功能的影响
- Author:
Chunwang HUANG
;
Kehong GAN
;
Shuzhen CONG
;
Zhanwu FENG
;
Ruili ZHOU
;
Zhaoqiu LIANG
- Publication Type:Journal Article
- Keywords:
Hyperlipidemias;
Ultrasonography,Doppler,color;
Cholesterol,HDL;
Carotid artery,common;
Elasticity
- From:
Chinese Journal of Medical Imaging
2015;(5):339-342,346
- CountryChina
- Language:Chinese
-
Abstract:
PurposeTo explore the value of ultrasound radio frequency technique in the quantitative evaluation of common carotid artery intima-media thickness (IMT) and elasticity change in patients with dyslipidemia, and to discuss the influence of high density lipoprotein cholesterol (HDL-C) upon carotid artery structure and elasticity function. Materials and Methods A hundred and fifty patients with abnormal serum lipid were selected as case group and further divided into three groups: group A--50 patients with hyperlipidemia and high HDL-C, group B--50 patients with hyperlipidemia and normal HDL-C, group C--50 patients with hyperlipidemia and low HDL-C. Meanwhile, 50 healthy people were enrolled in the study as control group (group D). The ultrasound radio frequency-data technique was employed to analyze the influence of hyperlipidemia and HDL-C upon IMT, CC,β, PWV and AIx.Results The IMT,β, PWV and AIx in group B were higher than those in group D, but group B had lower CC (the differences with statistic significance,t=5.141, 4.219, 4.898, 4.142 and-3.758,P<0.01). Compared with group A, group B had higher IMT,β, PWV and AIx and lower CC (the differences with statistic significance,t=3.425, 2.807, 2.913, 2.209 and-2.091,P<0.05 orP<0.01). Compared with group B, group C had higher IMT,β, PWV and AIx and lower CC (the differences with statistic significance,t=4.937, 2.195, 3.337, 2.067 and-3.049, P<0.05 orP<0.01). Group A had higher IMT and PWV than group D (the differences with statistic significance,t=2.236 and 2.407,P<0.05), but CC,β, and AIx showed no difference between group A and group D (t=-1.693, 1.845 and 1.967,P>0.05). In patients with hyperlipidemia, the increase of HDL-C led to the reduction of the common carotid artery IMT and wall stiffness and the increase of elasticity and vice versa.Conclusion The ultrasound radio frequency technique could measure the real-time common carotid artery IMT and elasticity automatically and accurately, thus provides reliable quantitative index for the evaluation of early artery structure and change of function in lipid lowering therapy.
