The expression and meaning of CD34,CD117,SMA,S -100 protein in gastrointestinal stromal tumor
10.3760/cma.j.issn.1008-6706.2015.10.019
- VernacularTitle:CD34、CD117、平滑肌肌动蛋白、S-100蛋白在胃肠道间质瘤中的表达及意义
- Author:
Runzhen ZHAO
;
Lin TIAN
;
Yonghong CHEN
;
Hongyao ZHAO
- Publication Type:Journal Article
- Keywords:
Gastrointestinal Stromal Tumor;
Smooth muscle actin;
S -100 protein;
Immunohistochemical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(10):1499-1501,1502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and relationship with the clinical pathological features of CD34,CD117,smooth muscle actin(SMA),S -100 protein in gastrointestinal stromal tumor.Methods 60 cases of resection of gastrointestinal stromal tumor specimens were collected,all cases were confirmed by postoperative patholo-gy,explored the expression of CD34,CD117,SMA,S -100 protein expression in gastrointestinal stromal tumor with immunohistochemical method,analyzed the relationship with the clinical pathological features of CD34,CD117,SMA, S -100 protein.Results CD34 positive signal located in the cytoplasm,CD117 positive signal mainly located in cyto-plasm,a few located in the cell membrane,nuclear yellow particles diffuse distribution in cells,SMA and S -100 pro-tein located in the cytoplasm of focal or scattered point positive expression of CD34,CD117,SMA,S -100 protein pos-itive expression rate in gastrointestinal stromal tumor tissue were 88.33% (53 /60),95.00% (57 /60),43.33%(26 /60)and 6.67% (4 /60);CD34 positive expression rate was related to area (χ2 =9.093,P <0.05),S -100 protein positive expression rate related to the histological type (χ2 =10.447,P <0.05).Conclusion CD34,CD117 in gastrointestinal stromal tumor tissue in the positive expression rate is very high,detection jointed with CD34,CD117 can improve the gastrointestinal stromal tumor diagnosis accuracy.
