The clinical efficacy of nicergoline combined with donepezil hydrochloride in the treatment of mild vascular dementia and its influence on cognitive function
10.3760/cma.j.issn.1008-6706.2015.10.022
- VernacularTitle:尼麦角林联合盐酸多奈哌齐治疗轻度血管性痴呆的临床疗效及对患者认知功能的影响
- Author:
Shuyuan MA
;
Yixin BAI
- Publication Type:Journal Article
- Keywords:
Nicergoline;
Donepezil Hydrochloride;
Dementia,Vascular;
Cognitive
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(10):1508-1509,1510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of nicergoline combined with donepezil hydrochlo-ride in the treatment of mild vascular dementia and its influence on cognitive function.Methods 66 patients with mild vascular dementia from neurology were divided into two groups by random numbers,33 cases in each group.On the based of the routine symptomatic treatment,the control group were given nicergoline,the observation group were treated with nicergoline combined with aricept.Four weeks was a course,both groups were continuously treated for 3 courses.Results The MMSE scores of the observation group after treatment was (36.7 ±5.7)points,which was significantly increased compared with before treatment(t =10.137,P <0.05)and the control group(t =11.236,P <0.05);The ADL score was(35.8 ±16.2)points,which was significantly lower compared with before treatment(t =10.825,P <0.05)and the control group(t =11.415,P <0.05);The total effective rate of the observation group was 78.9%,which was higher than 54.5% of the control group(χ2 =9.24,P <0.05).Conclusion Nicergoline com-bined with donepezil hydrochloride in the treatment of mild vascular dementia can significantly improve cognitive func-tion scores,and it is a significant effect,safe and reliable method.
