Effect of sodium hyaluronate combined with glucosamine in the treatment of knee osteoarthritis and its influence on knee joint function
10.3760/cma.j.issn.1008-6706.2015.10.025
- VernacularTitle:玻璃酸钠联合氨基葡萄糖治疗膝骨关节炎的疗效观察
- Author:
Yizhou LI
- Publication Type:Journal Article
- Keywords:
Sodium hyaluronate;
Glucosamine;
Osteoarthritis of the knee;
Injection,intra -articular
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(10):1517-1519,1520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of sodium hyaluronate combined with glucosamine in the treatment of knee osteoarthritis and its improving for knee joint function.Methods 127 patients with knee osteoar-thritis who were treated in our hospital from March 2011 to September 2013 were divided two groups according to the random number table method,the control group was intra -articular injected with sodium hyaluronate,while the obser-vation group was treated with oral glucosamine on the basis of control group therapy.Compared the clinical effect,the keen joint pain by the visual analogue score(VAS)method were evaluated,and the improving of knee joint function and adverse reaction status in two groups after treatment was analyzed.Results Patients were followed up for 3 months,observed in 42 cases,17 cases markedly effective group,progress in 4 cases,invalid 1 cases,in the control group 31 cases were markedly effective,effective in 20 cases,progress in 7 cases,5 cases were ineffective,with a sig-nificant difference between he ttwo groups(Z =-2.120,P =0.034).VAS scores in the two groups after treatment were reduced than before treatment,and the reduced extent in the observation group was bigger than the control group [(2.7 ±0.8)vs (4.2 ±1.0)],the difference was statistically significant(t =3.832,P =0.039).Knee joint func-tion score of the two groups after treatment were increased than before treatment,and increased extent in the observa-tion group was bigger than the control group[(88.9 ±11.8)vs (75.2 ±12.0)],the difference was statistically sig-nificant(t =3.261,P =0.016).There were adverse reactions in the two groups after treatment,but the difference was no statistically significant(P >0.05).Conclusion Sodium hyaluronate combined with glucosamine can significantly promote the clinical effect in the treatment of knee osteoarthritis,it can relieve pain,improve the recovery of knee joint function and will not increased the risk of adverse reaction of patients after treatment,which has an important value to be popularized in clinical field.
