Study analgesic effect site of eupatorium odoratum L and its mechanism
10.3969/j.issn.1671-8348.2015.03.008
- VernacularTitle:飞机草镇痛作用部位及其机制研究
- Author:
Ke YANG
;
Nina CAI
;
Xin YAN
- Publication Type:Journal Article
- Keywords:
plants;
chromolaena;
analgesia;
Eupatorium odoratum L
- From:
Chongqing Medicine
2015;(3):312-314,317
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the analgesic effect of Eupatorium odoratum L and its mechanism .Methods Mice were random‐ly divided into 6 groups .Swinging tail method in spinal cord destroyed mouse ,hot‐plate and twisted body method in naloxone blocked mouse ,and formalin‐induce inflammatory pain method were done to investigate the analgesic effect of Eupatorium odoratum L .Each pain index under each experiment condition was determined after intra gastric administration of each group of mice .The concentration of NO and PGE2 in serum and brain were measured to study its mechanisms .Results High‐dose of Eupatorium odor‐atum L significantly enhanced pain threshold in either spinal cord destroyed or naloxone blocked mouse with pain induced by hot and acetic acid(P<0 .05) .High and middle dosage groups of Eupatorium odoratum L markedly reduced the first‐and second‐phase re‐sponses of formalin‐induced inflammatory pain mouse(P< 0 .05) ,and decreased the writhing times and licking rear feet times caused by twisted body method(P<0 .05) .The level of NO and PGE2 in serum and brain of mouse induced by formalin were both decreased(P<0 .05) .Conclusion Eupatorium odoratum L has notable analgesic effect ,which may be related to reduce the level of NO and PGE2 in central and peripheral site .
