Research progress of β-arrestins in fibrotic diseases
10.3969/j.issn.1001-1978.2015.02.006
- VernacularTitle:β-arrestins与纤维化疾病的研究进展
- Author:
Yuanjing GU
;
Wuyi SUN
;
Sen ZHANG
;
Jingjing WU
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
β-arrestins;
firotic disease;
extracellular matrix;
G protein coupled receptor;
signal transduction;
receptor tyrosine ki-nase
- From:
Chinese Pharmacological Bulletin
2015;(2):170-174,175
- CountryChina
- Language:Chinese
-
Abstract:
β-arrestins, a kind of important adaptor protein and signal transduction protein found in the purification process ofβ-adrenergic receptor kinase (β-ARK) ,were first identified as pro-teins that have the ability to desensitize G protein-coupled recep-tors ( GPCR) . Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposi-tion of extracellular matrix ( ECM ) components including colla-gen . A large number of studies have shown thatβ-arrestins play an important role in the process of fibrotic diseases, involved in inflammatory response and excess deposition of ECM. This re-view discusses the research status and development prospects ofβ-arrestins-mediated fibrotic diseases.
