Recent research progress on the role of gap junction in neuropathic pain
10.3969/j.issn.1001-1978.2015.02.003
- VernacularTitle:缝隙连接与神经病理性痛的研究进展
- Author:
Lichao PENG
;
Shangdong LIANG
- Publication Type:Journal Article
- Keywords:
gap junction;
connexin;
nervous system;
glial cells;
neuropathic pain;
gap junction blocker
- From:
Chinese Pharmacological Bulletin
2015;(2):157-161,162
- CountryChina
- Language:Chinese
-
Abstract:
Gap junctions are specialized transmembrane channels that enable the direct exchange of materials and transfer chemical or electrical signaling between adjacent cells, thus maintaining cellular homeostasis. In the nervous system, gap junction chan-nels not only mediate intercellular coupling between neurons and between glial cells, but also can be involved in secondary dam-age under pathological conditions. Recently, some studies have shown that gap junctions play an important role in neuropathic pain caused by nervous system damage. Research on the role of gap junctions in neuropathic pain can contribute to a deeper un-derstanding of the pathogenesis of neuropathic pain, providing a new research direction for the treatment of neuropathic pain.
