Research on effect of central 5-HTergic system in early-onset depression
10.3969/j.issn.1001-1978.2015.01.005
- VernacularTitle:中枢5-HT能系统在早发性抑郁中的作用研究
- Author:
Liming ZHENG
;
Yafei SHI
;
Haomeng WU
;
Zhiwei XU
- Publication Type:Journal Article
- Keywords:
early-onset depression;
central 5-HTergic system;
5-HT;
5-HTT;
maturation;
SSRIs
- From:
Chinese Pharmacological Bulletin
2015;(1):19-22,23
- CountryChina
- Language:Chinese
-
Abstract:
Nowadays the pathogenesis of early-onset depression is still uncertain. Only SSRIs are currently approved for clinical use as antidepressants in children and adolescents, indicating that 5-HT is the most important neurotransmitter involved in the dis-ease. Current studies with regard to central 5-HTergic system in early-onset depression mainly focus on 5-HT synthesis deficien-cy, 5-HT transportation dysregulation, as well as the earlier mat-uration of 5-HT system than norepinephrine system. 5-HT precur-sor tryptophan malabsorption and dysregulation of 5-HT synthesis can contribute to 5-HT deficiency. Moreover, the 5-HTTLPR low-expressing genotypes may increase the risk of early-onset de-pression. It is necessary to make preclinical and clinical studies more widely and deeply about the effect of central 5-HTergic sys-tem in early-onset depression in future.
