Comparison of Anesthesia Effect of Ropivacaine and Bupivacaine in Combined Spinal Epidural Anesthesia in Abdominal Operation
- VernacularTitle:罗哌卡因与左旋布比卡因用于腹部手术腰硬联合麻醉效果比较
- Author:
Jianming SHEN
;
Pingping PANG
;
Huan WANG
;
Fan DING
- Publication Type:Journal Article
- Keywords:
Ropivacaine;
Levobupivacaine;
Combined spinal epidural anesthesia;
Anesthesia effect
- From:
China Pharmacist
2015;(1):83-84,132
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of ropivacaine and bupivacaine in combined spinal epidural anesthesia in abdominal operation. Methods:Totally 86 abdominal operation patients with combined spinal epidural anesthesia were randomly divid-ed into group A and group B with 43 ones in each. Group A was with ropivacaine anesthesia, while group B was with levobupivacaine anesthesia. The anesthesia effect, hemodynamic changes at different time points and adverse drug reactions were compared between the two groups. Results:The duration of sensory block in the two groups was not statistically different (P>0. 05), while the patients in group A had shorter motor nerve recovery time than those in group B (P<0. 05), and Bromege score of group A was significantly lower than that of group B (P<0. 05). After the onset of anesthesia block, all hemodynamic parameters (SBP, DBP and HR) in the two groups were lower than those before the anesthesia (P<0. 05), while at the end of anesthesia, the parameters showed no statistically significant difference from those before the anesthesia (P>0. 05). During the operation, the parameters at different time points in group A had no significant difference from those in group B (P>0. 05). The incidence of adverse drug reaction was not statistically significant between the two groups as well (P>0. 05). Conclusion:Ropivacaine and levobupivacaine show similar blocking effect on the sensory nerve with the same effects on hemodynamics and adverse reactions, however, the blocking effect of ropivacaine on motor nerve is weaker, which is more beneficial to the early exercise of the patients after operation.
