Three Mood Stabilizers for Inhibition of Ouabain-induced ERK1/2 Phosphorylation in Astrocytes
- VernacularTitle:三种情绪稳定剂抑制哇巴因上调星形胶质细胞ERK1/2磷酸化水平
- Author:
Jieyu LEI
;
Fanli WANG
;
Li GU
;
Dan SONG
;
Liang PENG
- Publication Type:Journal Article
- Keywords:
astrocyte;
mood stabilizer;
lithium carbonate;
carbamazepine;
sodium valproate;
ERK1/2;
ouabain
- From:
Journal of China Medical University
2015;(2):97-101,113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effets of three mood stabilizers on ouabain?induced ERK1/2 phosphorylation in astrocytes. Methods As?trocytes were treated with different agents and divided into different groups accordingly,namely,the control group with saline,the group with oua?bain,the group with mood stabilizers(lithium carbonate,carbamazepine,sodium valproate)and the group with ouabain+mood stabilizers. The phosphorylation of ERK1/2 in each group was analyzed by Western blot. Results Compared with saline and mood stabilizer groups,the phosphoryla?tion of ERK1/2 was increased in the ouabain group,with statistical significance(P<0.05). There was no significant difference in ERK1/2 phosphoryla?tion between the group with ouabain+mood stabilizers and the control or mood stabilizer group. Conclusion The three kinds of mood stabilizers can inhibit ouabain?induced ERK1/2 phosphorylation in astrocytes.
