Therapies of simvastatin on AECOPD combined with PAH through affecting VEGF and the pulmonary function
10.3969/j.issn.1671-8348.2015.06.015
- VernacularTitle:辛伐他汀对老年 COPD 合并 PAH 患者VEGF 水平及肺功能的影响
- Author:
Xi LIU
;
Xichun WANG
;
Dan GAN
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
pulmonary disease,chronic obstructive;
hypertension,pulmonary;
vascular endothelial growth factor;
lung function
- From:
Chongqing Medicine
2015;(6):761-762,765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of simvastatin on secretion of VEGF in blood serum and sputum of elderly chronic ob-structive pulmonary disease(COPD)combined with PAH patients and the pulmonary function.Methods Seventy cases of elderly COPD patients combined with PAH patients were randomized in two groups,namely the normal treatment group and combined sim-vastatin group (35 cases in each group),then compare the changes of the VEGF in blood serum,sputum and lung function.Results VEGF in blood serum and sputum showed significant changes after therapies of simvastatin (P <0.05).After 4 weeks′therapy, the FEV1% pre and FEV1/FVC increased significantly (P <0.05).Conclusion Normal treatment combine with simvastatin could decrease VEGF in blood serum and sputum of elderly COPD combined with PAH patients,meanwhile improve pulmonary function.
