Value of G6PI measurement in the diagnosis of rheumatoid arthritis
10.3969/j.issn.1673-4130.2015.03.013
- VernacularTitle:G6PI检测在类风湿关节炎诊断中的价值
- Author:
Yan WANG
;
Mingshu ZHOU
- Publication Type:Journal Article
- Keywords:
glucose-6-phophate isomerase;
rheumatoid arthritis;
cyclic citrullinated peptides;
rheumatoid factor
- From:
International Journal of Laboratory Medicine
2015;(3):317-318,321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of G6PI in the diagnosis of rheumatoid arthritis(RA).Methods The clinical data of 130 cases of patients with RA treated in the hospital from August 2011 to August 2013 were statistically analyzed.In addition to that,85 non-RA patients with other rheumatic diseases were recruited as non-RA group and 60 healthy people were recruited as control group.Results Serum G6PI,anti-CCP antibodies and RF concentrations of RA group were significantly higher than those of non-RA group and control group(P <0.05),the RF concentrations of non-RA group was significantly higher than those of con-trol group(P <0.05).The positive rates of G6PI,anti-CCP antibodies and RF tests were 67.7%(88/130),52.3%(68/130)and 75.4% (98/130)respectively in RA group,which were significantly higher than those in non-RA and control group(P <0.05),the serum RF concentrations in non-RA group were significantly higher than control group(P <0.05).The sensitivity,negative predic-tive value and Youden index of G6PI were significantly higher than those of anti-CCP and RF(P <0.05).Serum G6PI concentra-tions of RA patients was positively correlated with those of RF(r=0.732,P <0.05).Conclusion G6PI detection can be used in the diagnosis of RA,and is of great value.
