Analysis of the relationship between serum HBV-DNA And hepatic fibrosis
10.3969/j.issn.1673-4130.2015.03.017
- VernacularTitle:乙型肝炎患者血清HBV-DNA水平与肝纤维化指标的相关性分析
- Author:
Kai HU
;
Wen DENG
- Publication Type:Journal Article
- Keywords:
hepatitis B;
HBV-DNA;
hepatic fibrosis;
relationship
- From:
International Journal of Laboratory Medicine
2015;(3):326-327,330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between serum HBV-DNA and hepatic fibrosis in patients with hepatitis B. Methods Serum HBV-DNA load and hepatic fibrosis hyaluronic acid (HA),Ⅲ procollagen N terminal peptide(PⅢNP),laminin (LN),Ⅳ collagen(Ⅳ-C)of 154 cases were detected by real-time fluorescence quantitative PCR and chemiluminescence method. Statistical analysis of the correlation between HBV-DNA load and hepatic fibrosis indicator was performed.Results The data of HBV-DNA load after taking lg value was 5.49±1.39;The serum concentration of hepatic fibrosis HA was (166.95±148.20)ng/mL,PⅢNP was (12.14±7.37)ng/mL,Ⅳ-C was (65.29±45.48)ng/mL,LN was (59.52±35.67)ng/mL.The difference between experimental group and control group in hepatic fibrosis was significant(P <0.05).Serum HBV-DNA only correlated with LN(r=0.284,P =0.015).Conclusion There is no significant correlation between serum HBV-DNA and hepatic fibrosis in hepatitis B pa-tients.Anti-fibrosis treatment should also be strengthened for hepatitis B patients in the course of antiviral treatment.
