Clinicopathological features of six cases of calcifying aponeurotic fibroma
10.13315/j.cnki.cjcep.2015.01.010
- VernacularTitle:钙化性腱膜纤维瘤6例临床病理分析
- Author:
Le XIE
;
Rongjun MAO
;
Juan WANG
;
Jile FU
;
Fulan HAN
- Publication Type:Journal Article
- Keywords:
soft tissue neoplasm;
calcifying aponeurotic fibroma;
clinicopathological features;
histogenesis
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(1):40-43,47
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathologic features of calcifying aponeurotic fibroma (CAF). Methods The clinical and pathologic profiles of 6 cases of CAF were retrospectively analyzed. Results CAF appeared a firm, painless and slowly growing mass with a predilection for the distal portions of the extremities in young children and adolescents. Microscopically, the tumor consis-ted mainly of benign appearing spindle cells, chondroid cells and calcific debris. Immunohistochemically, the tumor cells were positive for vimentin, HHF-35, S-100, Calponin and CD68. Conclusion CAF is a rare, locally aggressive fibroblastic lesion. It can make an accurate diagnosis by integrating the clinical location with histopathological features. Repeated minor trauma to the extremities and some embryologic cell nests maybe its pathogenesis.
