Application of fluorescence in situ hybridization and chromosome karyotype analysis in prenatal diagnosis
10.3969/j.issn.1673-4130.2015.04.029
- VernacularTitle:荧光原位杂交技术与染色体核型分析在产前诊断中的应用
- Author:
Haiyan ZENG
;
Jie WU
- Publication Type:Journal Article
- Keywords:
fluorescence in situ hybridization;
prenatal diagnosis;
karyotype analysis
- From:
International Journal of Laboratory Medicine
2015;(4):501-502,505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of fluorescence in situ hybridization (FISH)in prenatal diagnosis and compared with karyotype analysis of cells from amniotic fluid.Methods A total of 183 high-risk pregnant women received for a FISH and karyotype analysis who taken prenatal disgnosis in Meizhou people′s hospital between April 2012 and November 2013. Results According to the test results of karyotype analysis.There were 9 cases of chromosomal abnormality in 183 pregnant women.Among 9 cases,3 cases were trisomy 21,3 cases were trisomy 18,2 cases were XO and one case of XXY.One case of tri-somy 18 was showed normal using the FISH.Other cases were consistent with karyotype analysis result.Conclusion FISH is a rapid,reliable and prompt prenatal diagnosis method,combined with karyotype analysis will maximize the detection efficacy in pre-natal diagnosis of chromosome abnormalities.
