Research on Preparation Technology of Xiaoer Qingfei Dispersible Tablets
10.3969/j.issn.1005-5304.2015.03.022
- VernacularTitle:小儿清肺分散片制备工艺研究
- Author:
Yan SUN
;
Qingjie MENG
;
Lin YAO
;
Weiming WANG
- Publication Type:Journal Article
- Keywords:
Xiaoer Qingfei Dispersible Tablets;
preparation technology;
prescription optimization
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(3):83-85,86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription of preparation technology of Xiaoer Qingfei Dispersible Tablets. Methods The filler, disintegrant, adhesive, lubricant, and drug loading were screened by single factor tests. The combined application proportion of three disintegrating agents, PVPP, CMS-Na, and L-HPC, were optimized by orthogonal test. Results The best prescription of preparation technology of dispersible tablets:microcrystalline cellulose as filler;silica gel powder as lubricant;75%alcohol as the adhesive;PVPP, L-HPC, and CMS-Na as combined disintegrants (L-HPC∶PVPP∶CMS-Na=4∶3∶6). The disintegration time of prepared dispersible tablets was less than 3 minutes, and all through the No.2 sieve. Dispersible uniformity was in accordance with the provisions. Conclusion Xiaoer Qingfei Dispersible Tablets prepared by the optimized preparation process are stable and feasible, and suitable for clinical application.
