Different expression of NK cells in patients with advanced small cell lung cancer and non-small cell lung cancer
10.3969/j.issn.1000-484X.2015.02.025
- VernacularTitle:小细胞和非小细胞肺癌晚期患者NK细胞表达的差异
- Author:
Shanshan WU
- Publication Type:Journal Article
- Keywords:
Small cell lung cancer;
Non-small cell lung cancer;
Advanced lung cancer;
NK cells;
NSCLC;
SCLC
- From:
Chinese Journal of Immunology
2015;(2):250-252,260
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the different expression of NK cells between patients with advanced small cell lung cancer and with non-small cell lung cancer , as well as providing available reference for clinical treatment.Methods: Peripheral blood was taken from 65 patients with advanced lung cancer which was included 14 cases of small cell lung cancer and 51 cases of non-small cell lung cancer,20 cases normal controls.The expression of NK cells was analyzed with flow cytometry.Results: We found that the percentage of NK cells in advanced small cell lung cancer patients was much more than that of normal controls .There was no significant variation in the percentage of NK cells between advanced non-small cell lung cancer patients and normal controls.The percentage of NK cells was negatively correlated with the percentage of CD 4+T cells in patients with advanced lung cancer .Conclusion:The percentage of NK cells in advanced small cell lung cancer patients was higher than normal controls ,the innate immunity could become a powerful supplement to the cellular immunity which was severely damaged .But the hypothesis needs to be further research.
