Advances in innate lymphoid cells
10.3969/j.issn.1000-484X.2015.02.001
- VernacularTitle:固有淋巴细胞研究进展
- Author:
Hui PENG
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
Innate lymphoid cells;
Mucosal immunity;
Phenotype;
Function;
Development
- From:
Chinese Journal of Immunology
2015;(2):145-150,155
- CountryChina
- Language:Chinese
-
Abstract:
Natural killer (NK) cells have long been considered the only representative of lymphocyte lineages among the innate immune system ,but recent studies have revealed that several types of innate lymphoid cells ( ILC ) exist in both humans and mice.These newly identified ILC populations were mainly distributed at mucosal barriers ,regardless of their rarity ,they play important roles in the defense against pathogens and in the maintenance of tissue or organ homeostasis .In the early stages of ILC development ,a common ILC lineage-restricted progenitor exists and under the control of different transcription factors ,the progenitor can later give rise to different ILC subsets with distinct phenotypes and functions.Different ILC subsets exhibit distinct cytokine secretion profiles ,based on the categorization of helper T cell subsets , ILC family has been further classified into three groups.The finding of diverse ILC extremely enriches the content of innate immunity ,and also provides new insights into links between innate and adaptive immunity .
