Study of hydrodynamic in vitro and animal experiment of a homebred pneumatic pulsatile ventricular assist device
10.11958/j.issn.0253-9896.2015.07.011
- VernacularTitle:国产气动搏动性心室辅助装置的体外流体力学及动物实验观察
- Author:
Guoning SHI
;
Qingliang CHEN
;
Tongyun CHEN
;
Jianshi LIU
- Publication Type:Journal Article
- Keywords:
heart,artificial;
heart-assist devices;
hemodynamics;
animal experimentation;
ventricular assist device;
hydromechanics
- From:
Tianjin Medical Journal
2015;(7):742-744,745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study in vitro hydrodynamics of a pneumatic pulsatile ventricular assist device developed ex?clusively by China, and establish an animal model for the detection by the device. Methods The hydromechanics experi?ment was performed on an in vitro test loop using MEDOS-System to drive the ventricular assist device, and lycerl-water so?lution was used as circulating medium. The changes of afterload pressure and the output of the pump were monitored, and the impermeability and stability were also assessed after the experiment. Six adult dogs were used as the experimental animals. The device worked in the left heart assistance mode for 1 hour then the ventricular fibrillation was induced by potassium chloride, and then defibrillated after 5 min while the device remained working. The hemodynamics data were monitored con?secutively during the trial. Results The ventricular assist device worked stably and reliably during the hemodynamic exper?iment. The pump can generate more than 4 L/min flow against the afterload pressure of 100 mmHg. There were no significant changes in heart rate at different time points in experimental dogs after left ventricular assist. Comparison between after auxil?iary immediately and former auxiliary, the diastolic blood pressure of dogs increased 30 mmHg with the ventricular assist, and the diastolic pressure increased 19 mmHg. No obvious fluctuation in blood pressure was found during the auxiliary pro?cess. The diastolic blood pressure stayed at 60 mmHg when the heart was in ventricular fibrillation, and returned to normal after electrical defibrillation. Conclusion The ventricular assist device works stably in vitro test, and the pump can meet the need of adult’s ventricular assist. It is effective and security to dogs in short term. The effects of long-term use need to be future proved.
