MTHFR 677 C/T polymorphism-new ideas about depressive disorder treatment
10.3969/j.issn.1001-1978.2015.07.006
- VernacularTitle:MTHFR-C677 T基因多态性-抑郁症治疗的新思路
- Author:
Wanwan LIU
;
Xianzhe DONG
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
genetic factor;
MTHFR-677C/T polymorphism;
Hcy;
folate;
neurotransmitter;
depression
- From:
Chinese Pharmacological Bulletin
2015;(7):915-918,919
- CountryChina
- Language:Chinese
-
Abstract:
It has been confirmed that genetic factor plays an im-portant role in the pathogenesis of depression. MTHFR is one of the key enzymes in folate and homocysteine ( Hcy ) metabolism which participates in Alzheimer’ s disease, depression and other mental illnesses. MTHFR-677C/T polymorphism causes the de-crease of enzyme activity and heat resistance, which will lead to lower folate and elevated plasmal Hcy concentration. All of these results put together will cause the central neuronal damage and microvascular damage and affect the synthesis of central neuro-transmitter and methylation of biogenic amines and phospholipids in the central nervous system, which will eventually induce vari-ous mental illnesses like depression, etc. This article reviews the research advancement in the relationship between MTHFR-677C/T polymorphism and depression in recent years on the basis of MTHFR gene mutation and function, lack of folic acid, elevated plasma homocysteine levels and the MTHFR-C677T polymor-phism. Based on which we hope to bring new ideas about treat-ment of depression.
