Role of mitochondrial damage and repair in Parkinson′s disease
10.3969/j.issn.1001-1978.2015.07.004
- VernacularTitle:线粒体损伤与修复在帕金森病中的作用
- Author:
Jie DENG
;
Yifang LI
;
Kurihara HIROSHI
;
Rongrong HE
- Publication Type:Journal Article
- Keywords:
PD;
mitochondrial damage;
mitophagy;
Parkin;
PINK1;
cardiolipin;
natural medicine
- From:
Chinese Pharmacological Bulletin
2015;(7):906-909,910
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson’ s disease ( PD) is a common disease in central nervous system, for which an effective treatment has yet to be found. The causes of PD include genetic, environmental, aging factors, etc. There is a common factor which can lead to the degeneration of dopaminergic neurons in the substantia:mito-chondrial damage and repair. This paper has summarized the en-vironmental and genetic factors that can cause mitochondrial damage in dopaminergic neurons, and outlined several mitochon-drial repairing pathways ( such as mitophagy) in the treatment of PD. It also analyzes the research situation of utilizing natural medicine in the therapy of PD from the perspective of the mito-chondrial protection.
