Detection of tumor marker CA199 and CA153 in rheumatoid arthritis and its clinical significance
10.3969/j.issn.1673-4130.2015.05.005
- VernacularTitle:类风湿关节炎患者血清肿瘤标志物 CA199及 CA153检测及临床意义
- Author:
Baozhen LI
;
Hanyou MO
;
Yuhong SHI
;
Jia XU
;
Limei LI
- Publication Type:Journal Article
- Keywords:
arthritis;
rheumatoid;
tumor marker;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2015;(5):586-587,590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum tumor markers levels with the disease condition activity and the tumor occurrence in the patients with rheumatoid arthritis(RA).Methods Serum tumor marker CA199,CA153 levels were de-tected in 35 patients with RA (RA group)and 31 healthy controls(normal control group).ESR and CRP were examined and the disease activity (DA)was assessed by the DAS28 score in the RA group.The serum tumor markers levels and the positive rates were compared between the RA group and the normal control group.The correlation between the serum tumor markers levels with ESR,CRP and DAS28 score was analyzed.Results Serum levels and positives rate of CA199,CA153 in the RA group were higher than those in the control group(P <0.05).The serum CA153 level had a positive correlation with the ESR,CRP and DAS28 score in the RA group(P <0.05),but the serum CA199 level had no significant correlation with them.Conclusion The serum levels and positive rates of CA199 and CA199 could be increased in the patients with RA,moreover the increase of serum CA153 level is corre-lated with DA of RA.Therefore the serum tumor marker CA153 level may be used as one of reference indexes for evaluating the DA in the patients with RA.
