Diagnostic and staging value of orbital structures quantitative measurement with 3T magnetic resonance imaging in Graves’ophthalmopathy
10.3969/j.issn.1002-1671.2015.07.006
- VernacularTitle:3T-MRI 定量测量在 Graves 眼病诊断及分期中的价值
- Author:
Hao HU
;
Xiaoquan XU
;
Feiyun WU
;
Lianliang ZHANG
;
Haibin SHI
;
Huanhuan CHEN
- Publication Type:Journal Article
- Keywords:
Graves’ophthalmopathy;
magnetic resonance imaging;
quantitative measurement;
clinical active score
- From:
Journal of Practical Radiology
2015;(7):1082-1085,1099
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic and staging value of orbital structures quantitative measurement with 3T mag-netic resonance imaging in patients with Graves’ophthalmopathy (GO).Methods Twenty-three GO patients (patient group)and eighteen healthy volunteers (contrast group)were enrolled.Quantitative measurement of orbital structures including exophthalmos values,fatty tissue thickness of the inner side of eye balls,cross-sectional areas of extraocular muscles and signal intensity ratios of extraocular muscles to the ipsilateral temporal muscles (SIR values),and they were compared between two groups.Correlations be-tween the quantitative values and clinical active score (CAS)were accessed.Receiver operating characteristic (ROC)analysis was performed to evaluate the most relevant quantitative parameter and its diagnostic value in discriminating active from inactive GO pa-tients.Results There were significant differences between the GO group and contrast group regarding to all the quantitative parame-ters (P <0.05).Strong correlation was found between SIR values and CAS (r =0.730,P <0.001 ).Significant difference of SIR was found between patients with active GO and inactive GO (P =0.002),and a cut off value of 3.25 might be the critical threshold value,with diagnostic sensitivity of 81.8% and specificity of 83.3% respectively.Conclusion Quantitative measurement of orbital structures with 3T MR imaging could provide assistant in diagnosing and staging of GO.
